Team A: Stereo EEG in epilepsy patients

Principal Investigators

• Goal 1: Collaborating with clinicians to develop a comprehensive sEEG database as a first step towards understanding the role of different brain regions in diverse cognitive functions (e.g. attention, decision making).
• Goal 2: Exploring ways to combine different imaging modalities (e.g. dMRI, fMRI, scalp EEG) to develop a tool to enable better localization of epileptogenic networks.
• Goal 3: A tertiary goal is testing the effect of intracortical stimulation on neural activity and behaviour.
• These goals will pave the way for developing invasive co-processors in stroke patients.

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Team B: Non-invasive brain co-processors for stroke patients

Principal Investigators

• Goal 1: Collecting scalp EEG recordings from healthy participants/stroke patients and developing models for decoding cognitive functions (e.g. attention or decision-making).
• Goal 2: Developing passive controllers (including prosthetic devices e.g. switch that turns on or off based on decoding attention) and active neurofeedback systems (includes integrated neurostimulation e.g. tACS devices).
• Goal 3: Integrating these into a neuromorphic device with a small form factor as wearable technology.
• These goals can be piloted in healthy participants and then tested with stroke patients to understand challenges unique to such patients. This will require the involvement of clinicians who deal with stroke patients and with non-invasive rehabilitation.
• These goals will also pave the way for hybrid or minimally invasive co-processors for stroke patients.

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Team C: Invasive brain co-processors for stroke patients

Principal Investigators

• Goal 1: Building algorithms for decoding and re-encoding activity in the animal brain with existing, approved technologies (e.g. Utah arrays). As a first step, this could involve decoding activity in visuo-motor tasks because these are considerably simpler to train than cognitive tasks in either primate or rodent models.
• Goal 2: Building low-cost, invasive electrodes for decoding and/or re-encoding activity back in animal brains. This will include development of biocompatible electrodes as well as novel, multi-contact electrode technologies for simultaneous recording and stimulation.
• Goal 3: Building and testing invasive neuromorphic co-processors in animal models. Combining the deliverables of Goals 1 and 2, a neuromorphic co-processor will be developed for testing in animal models. As the ultimate aim is to translate the deliverables to human patients, in the long term, this goal will necessarily involve both animal and human (patient) work.

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